RADICAL CYCLIZATION TO APORPHINES - A NEW, EFFICIENT TOTAL SYNTHESIS OF THE APORPHINE GLAUCINE AND THE 4,5-DIOXOAPORPHINE PONTEVEDRINE, AND THE FIRST TOTAL SYNTHESIS OF 5-OXOAPORPHINES

被引：27

作者：

ESTEVEZ, JC ^{[1
]}

VILLAVERDE, MC ^{[1
]}

ESTEVEZ, RJ ^{[1
]}

CASTEDO, L ^{[1
]}

机构：

[1] UNIV SANTIAGO COMPOSTELA,FAC QUIM,DEPT QUIM ORGAN,E-15706 SANTIAGO,SPAIN

来源：

TETRAHEDRON | 1994年 / 50卷 / 07期

关键词：

D O I：

10.1016/S0040-4020(01)85073-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We describe the radical cyclization of bromobenzylisoquinolines and benzylisoquinolin-3-ones, which afford aporphines or the novel 5-oxoaporphines and 5-oxodehydroaporphines respectively. Oxidation of the latter compounds provides a new route to 4,5-dioxoaporphines.

引用

页码：2107 / 2114

页数：8

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