THE SYNTHESIS AND BIOLOGICAL-ACTIVITY OF 1-(2-DEOXY-4-THIO-ALPHA-L-THREO-PENTOFURANOSYL)THYMINE

被引：33
作者：
TIWARI, KN
MONTGOMERY, JA
SECRIST, JA
机构：
[1] Southern Research Institute, Organic Chemistry Research Department, Birmingham, Alabama
来源：
NUCLEOSIDES & NUCLEOTIDES | 1993年 / 12卷 / 08期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1080/07328319308018554
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The procedure of Huang and Hui (Nucleosides & Nucleotides 1993, 12, 139-147) was found to give benzyl 3,5-di-O-benzyl-2-deoxy-1,4-dithio-alpha-L-threo-pentofuranoside (6) rather than the claimed D-erythro isomer. This sugar was converted to an anomeric mixture of the thymine nucleosides. The mixture was separated and the alpha-anomer (alpha-10) was found to be cytotoxic, whereas the beta-anomer (beta-10) was inactive.
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页码：841 / 846
页数：6
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