INSECT IMMUNITY - THE DIPTERICIN PROMOTER CONTAINS MULTIPLE FUNCTIONAL REGULATORY SEQUENCES HOMOLOGOUS TO MAMMALIAN ACUTE-PHASE RESPONSE ELEMENTS

被引：51

作者：

GEORGEL, P ^{[1
]}

MEISTER, M ^{[1
]}

KAPPLER, C ^{[1
]}

LEMAITRE, B ^{[1
]}

REICHHART, JM ^{[1
]}

HOFFMANN, JA ^{[1
]}

机构：

[1] CNRS,UA 1490,BIOL GEN LAB,F-67000 STRASBOURG,FRANCE

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 197卷 / 02期

关键词：

D O I：

10.1006/bbrc.1993.2508

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We are using the diptericin gene as a model system to study the control of expression of the genes encoding antibacterial peptides during the Drosophila immune reaction. In order to investigate the putative regulatory regions in the diptericin promoter, we performed DNaseI footprinting experiments combined with gel-shift assays in two inducible systems: the larval fat body and a tumorous Drosophila blood cell line. Our results confirm the importance of κB-like elements previously described in the immune response of insects and reveal for the first time the involvement of other regions containing sequences homologous to mammalian acute-phase response elements. © 1993 Academic Press, Inc.

引用

页码：508 / 517

页数：10

共 21 条

[1] A NUCLEAR FACTOR FOR IL-6 EXPRESSION (NF-IL6) IS A MEMBER OF A C/EBP FAMILY [J].