HIV-1-SPECIFIC RT INHIBITORS - HIGHLY SELECTIVE INHIBITORS OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 THAT ARE SPECIFICALLY TARGETED AT THE VIRAL REVERSE-TRANSCRIPTASE

被引:183
作者
DECLERCQ, E
机构
[1] Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven
关键词
D O I
10.1002/med.2610130303
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
[No abstract available]
引用
收藏
页码:229 / 258
页数:30
相关论文
共 53 条
[1]   HIGHLY POTENT AND SELECTIVE-INHIBITION OF HIV-1 REPLICATION BY 6-PHENYLTHIOURACIL DERIVATIVES [J].
BABA, M ;
SHIGETA, S ;
TANAKA, H ;
MIYASAKA, T ;
UBASAWA, M ;
UMEZU, K ;
WALKER, RT ;
PAUWELS, R ;
DECLERCQ, E .
ANTIVIRAL RESEARCH, 1992, 17 (04) :245-264
[2]  
BABA M, 1991, MOL PHARMACOL, V39, P805
[3]   POTENT AND SELECTIVE-INHIBITION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV-1) BY 5-ETHYL-6-PHENYLTHIOURACIL DERIVATIVES THROUGH THEIR INTERACTION WITH THE HIV-1 REVERSE-TRANSCRIPTASE [J].
BABA, M ;
DECLERCQ, E ;
TANAKA, H ;
UBASAWA, M ;
TAKASHIMA, H ;
SEKIYA, K ;
NITTA, I ;
UMEZU, K ;
NAKASHIMA, H ;
MORI, S ;
SHIGETA, S ;
WALKER, RT ;
MIYASAKA, T .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (06) :2356-2360
[4]   ANTI-HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 ACTIVITIES AND PHARMACOKINETICS OF NOVEL 6-SUBSTITUTED ACYCLOURIDINE DERIVATIVES [J].
BABA, M ;
DECLERCO, E ;
IIDA, S ;
TANAKA, H ;
NITTA, I ;
UBASAWA, M ;
TAKASHIMA, H ;
SEKIYA, K ;
UMEZU, K ;
NAKASHIMA, H ;
SHIGETA, S ;
WALKER, RT ;
MIYASAKA, T .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1990, 34 (12) :2358-2363
[5]   HIGHLY SPECIFIC-INHIBITION OF HUMAN IMMUNODEFICIENCY VIRUS TYPE-1 BY A NOVEL 6-SUBSTITUTED ACYCLOURIDINE DERIVATIVE [J].
BABA, M ;
TANAKA, H ;
DECLERCQ, E ;
PAUWELS, R ;
BALZARINI, J ;
SCHOLS, D ;
NAKASHIMA, H ;
PERNO, CF ;
WALKER, RT ;
MIYASAKA, T .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 165 (03) :1375-1381
[6]   SYNERGISTIC INHIBITION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REPLICATION BY 5-ETHYL-1-ETHOXYMETHYL-6-(PHENYLTHIO)URACIL (E-EPU) AND AZIDOTHYMIDINE INVITRO [J].
BABA, M ;
ITO, M ;
SHIGETA, S ;
TANAKA, H ;
MIYASAKA, T ;
UBASAWA, M ;
UMEZU, K ;
WALKER, RT ;
DECLERCQ, E .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1991, 35 (07) :1430-1433
[7]   [2',5'-BIS-O-(TERT-BUTYLDIMETHYLSILYL)]-3'-SPIRO-5''-(4''-AMINO-1'',2''-OXATHIOLE-2'',2''-DIOXIDE) (TSAO) DERIVATIVES OF PURINE AND PYRIMIDINE NUCLEOSIDES AS POTENT AND SELECTIVE INHIBITORS OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 [J].
BALZARINI, J ;
PEREZPEREZ, MJ ;
SANFELIX, A ;
VELAZQUEZ, S ;
CAMARASA, MJ ;
DECLERCQ, E .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1992, 36 (05) :1073-1080
[8]   2',5'-BIS-O-(TERT-BUTYLDIMETHYLSILYL)-3'-SPIRO-5''-(4''-AMINO-1',2''-OXATHIOLE-2'',2''-DIOXIDE)PYRIMIDINE (TSAO) NUCLEOSIDE ANALOGS - HIGHLY SELECTIVE INHIBITORS OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 THAT ARE TARGETED AT THE VIRAL REVERSE-TRANSCRIPTASE [J].
BALZARINI, J ;
PEREZPEREZ, MJ ;
SANFELIX, A ;
SCHOLS, D ;
PERNO, CF ;
VANDAMME, AM ;
CAMARASA, MJ ;
DECLERCQ, E .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (10) :4392-4396
[9]  
BALZARINI J, 1992, J BIOL CHEM, V267, P11831
[10]   3'-SPIRO NUCLEOSIDES, A NEW CLASS OF SPECIFIC HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INHIBITORS - SYNTHESIS AND ANTIVIRAL ACTIVITY OF [2',5'-BIS-O-(TERT-BUTYLDIMETHYLSILYL)-BETA-D-XYLO AND RIBOFURANOSE]-3'-SPIRO-5''-[4''-AMINO-1'',2''-OXATHIOLE 2'',2''-DIOXIDE] (TSAO) PYRIMIDINE NUCLEOSIDES [J].
CAMARASA, MJ ;
PEREZPEREZ, MJ ;
SANFELIX, A ;
BALZARINI, J ;
DECLERCQ, E .
JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (15) :2721-2727