THE NUDE-MOUSE AS AN INVIVO MODEL FOR HUMAN BREAST-CANCER INVASION AND METASTASIS

被引：28
作者：
BRUNNER, N
BOYSEN, B
ROMER, J
SPANGTHOMSEN, M
机构：
[1] RIGSHOSP,FINSEN LAB,DK-2100 COPENHAGEN,DENMARK
[2] UNIV COPENHAGEN,INST PATHOL ANAT,DK-1168 COPENHAGEN,DENMARK
来源：
BREAST CANCER RESEARCH AND TREATMENT | 1993年 / 24卷 / 03期
关键词：
GENETIC LABELING; LACZ TRANSFECTANTS; METASTASIS MODELS; MICROMETASTASIS DETECTION; NUDE MICE;
D O I：
10.1007/BF01833265
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Human breast cancer xenografts only rarely invade and metastasize in nude mice. and have therefore only had limited use as a model for studying mechanisms involved in breast cancer spreading. However, recent reports describe differences not only between various cell lines but also between strains of immune-deficient mice in terms of providing a model for studies of the invasive and metastatic capability of human breast cancer xenografts. Genetic labelling of human cancer cells with the lacZ gene is described as a specific and highly sensitive method for identification of micrometastases in such a model.
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收藏
页码：257 / 264
页数：8
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