DECORPORATION OF PLUTONIUM BY ORAL-ADMINISTRATION OF A PARTIALLY LIPOPHILIC POLYAMINOCARBOXYLIC ACID

被引：3

作者：

MILLER, SC ^{[1
]}

BRUENGER, FW ^{[1
]}

KUSWIKRABIEGA, G ^{[1
]}

LLOYD, RD ^{[1
]}

机构：

[1] SIMONSEN LABS, GILROY, CA 95020 USA

来源：

HEALTH PHYSICS | 1992年 / 63卷 / 02期

关键词：

CHELATION; PLUTONIUM; RADIOACTIVITY; REMOVAL OF; DECONTAMINATION;

D O I：

10.1097/00004032-199208000-00007

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

A new, orally administered, partially lipophilic polyaminocarboxylic acid chelator was tested for its ability to remove incorporated Pu-239 deposits in rats. Animals were injected with Pu-239-citrate and 14 d later were treated for an additional 10 d with docosyl-triethylenetetraminepentaacetic acid (C22TT) added to the diet. There were significant reductions in the Pu-239 content of selected organs in the chelated animals compared with controls. These results suggest that this class of chelators should be studied further for their ability to remove plutonium deposits from the body when given orally.

引用

页码：195 / 197

页数：3

共 3 条

[1] PHARMACOLOGICAL PROPERTIES OF ORALLY AVAILABLE, AMPHIPATHIC POLYAMINOCARBOXYLIC ACID CHELATORS FOR ACTINIDE DECORPORATION
Miller, Scott C.
Wang, Xuli
Bowman, Beth M.
HEALTH PHYSICS, 2010, 99 (03): : 408 - 412
[2] Distribution study of radioactivity in rats after oral administration of the lipido/sterolic extract ofSerenoa repens (Permixon®) supplemented with [1-14C]-lauric acid, [1-14C]-oleic acid or [4-14C]-β-sitosterol
G. Chevalier
P. Benard
H. Cousse
T. Bengone
European Journal of Drug Metabolism and Pharmacokinetics, 1997, 22 : 73 - 83
[3] Distribution study of radioactivity in rats after oral administration of the lipido/sterolic extract of Serenoa repens (Permixon(R)) supplemented with [1-C-14]-lauric acid, [1-C-14]-oleic acid or [4-C-14]-beta-sitosterol
Chevalier, G
Benard, P
Cousse, H
Bengone, T
EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 1997, 22 (01) : 73 - 83

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