NEPHROTOXICITY OF PARA-AMINOPHENOL .1. EFFECT ON MICROSOMAL CYTOCHROMES, GLUTATHIONE AND COVALENT BINDING IN KIDNEY AND LIVER

被引：64

作者：

CROWE, CA ^{[1
]}

YONG, AC ^{[1
]}

CALDER, IC ^{[1
]}

HAM, KN ^{[1
]}

TANGE, JD ^{[1
]}

机构：

[1] UNIV MELBOURNE,DEPT ORGAN CHEM,PARKVILLE 3052,VICTORIA,AUSTRALIA

来源：

CHEMICO-BIOLOGICAL INTERACTIONS | 1979年 / 27卷 / 2-3期

基金：

澳大利亚研究理事会; 英国医学研究理事会;

关键词：

D O I：

10.1016/0009-2797(79)90128-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

p-Aminophenol administration lowered the microsomal cytochrome P-450 and b5 content and decreased the activity of NADPH cytochrome c reductase in kidney, but not in liver. Kidney GSH was depleted to 29% of the control value at 2 h, and only partly restored (50% of control) at 24 h. Liver GSH was transiently decreased, the lowest levels (77% of control) occurring at 30 min. The maximum level of covalently bound radioactivity was at two hours when 16.8% of the total radioactivity in kidney, 1.5% in liver and 3.6% in plasma was protein bound. At this time 81% of the total radioactivity in kidney and 95% of that in the liver was present in the soluble fraction. © 1979.

引用

页码：235 / 243

页数：9

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