P53 ALTERATIONS SHOW SIGNIFICANT CORRELATION WITH GENE AMPLIFICATION AND S-PHASE INDEX IN BREAST-CANCER

被引：0

作者：

CERVANTES, M

ZHOU, HY

SAHIN, A

DHINGRA, K

VALERO, V

ORDONEZ, N

ELNAGGAR, A

HESS, K

GLASSMAN, A

SEN, S

机构：

[1] UNIV TEXAS, MD ANDERSON CANC CTR, DIV LAB MED, HOUSTON, TX 77030 USA

[2] UNIV TEXAS, MD ANDERSON CANC CTR, DIV PATHOL, HOUSTON, TX 77030 USA

[3] UNIV TEXAS, MD ANDERSON CANC CTR, DEPT BREAST & GYNECOL MED ONCOL, HOUSTON, TX 77030 USA

[4] UNIV TEXAS, MD ANDERSON CANC CTR, DEPT BIOMATH, HOUSTON, TX 77030 USA

来源：

INTERNATIONAL JOURNAL OF ONCOLOGY | 1995年 / 6卷 / 05期

关键词：

P53; ONCOGENES; FLOW CYTOMETRY; BREAST CANCER;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Correlation of p53 gene/protein alterations with incidence of oncogene amplification, a potential marker of prognosis, was evaluated in 26 fresh breast cancer samples. p53 gene was analyzed by SSCP and DNA sequencing while p53 protein status was investigated by immunohistochemistry (IH). Amplification of c-erbB2/neu, c-myc, N-ras, int-2, hst, PRAD-1 and EGFR genes was studied by slot blot and in situ hybridizations. p53 alterations were found in 31% cases by SSCP and 42% by IH; gene amplification was detected in 27% cases. p53 gene alterations correlated significantly with gene amplification (p=0.006) and also with higher S-phase index (p=0.026), aneuploidy (p=0.026) and negative progesterone receptor status (p=0.043).

引用

页码：955 / 962

页数：8

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