IDARUBICIN IS ACTIVE ON MDR CELLS - EVALUATION OF DNA-SYNTHESIS INHIBITION ON P388 CELL-LINES

被引：13
作者：
PETRINI, M
MATTII, L
VALENTINI, P
SABBATINI, ARM
GRASSI, B
GRANDI, M
机构：
[1] UNIV PISA,DEPT HEMATOL,I-56100 PISA,ITALY
[2] FARMITALIA CARLO ERBA SPA,RES INST,DEPT EXPTL ONCOL,I-20014 NERVIANO,ITALY
来源：
ANNALS OF HEMATOLOGY | 1993年 / 67卷 / 05期
关键词：
IDARUBICIN; MULTIDRUG RESISTANCE; P-170; LEUKEMIA;
D O I：
10.1007/BF01715052
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Multidrug resistance is frequently found in patients affected by hematological malignancies and has been related to a poor prognosis of acute leukemia. In the present paper we report results concerning the activity of idarubicin, an anthracycline derivative, on the leukemic P388 and P388 doxorubicin-resistant cell lines. The results clearly show that idarubicin inhibits DNA synthesis in the resistant cell line more actively than doxorubicin.
引用
收藏
页码：227 / 230
页数：4
相关论文
共 22 条
[1]   MULTIDRUG RESISTANCE AND ITS CIRCUMVENTION [J].
BECK, WT .
EUROPEAN JOURNAL OF CANCER, 1990, 26 (04) :513-515
[2]  
BERMAN E, 1991, BLOOD, V77, P1666
[3]  
BERMAN E, 1992, BLOOD, V79, P3267
[4]   TREATMENT OF CHILDREN WITH REFRACTORY ACUTE LYMPHOCYTIC-LEUKEMIA WITH VINCRISTINE AND DILTIAZEM [J].
BESSHO, F ;
KINUMAKI, H ;
KOBAYASHI, M ;
HABU, H ;
NAKAMURA, K ;
YOKOTA, S ;
TSURUO, T ;
KOBAYASHI, N .
MEDICAL AND PEDIATRIC ONCOLOGY, 1985, 13 (04) :199-202
[5]  
CARULLI G, 1990, HAEMATOLOGICA, V75, P300
[6]  
CARULLI G, 1990, HAEMATOLOGICA, V75, P516
[7]  
CARULLI G, 1990, HAEMATOLOGICA, V75, P363
[8]   CHARACTERIZATION BY SOMATIC-CELL GENETICS OF A MONOCLONAL-ANTIBODY TO THE MDR1 GENE-PRODUCT (P-GLYCOPROTEIN) - DETERMINATION OF P-GLYCOPROTEIN EXPRESSION IN MULTI-DRUG-RESISTANT KB AND CEM CELL VARIANTS [J].
CENCIARELLI, C ;
CURRIER, SJ ;
WILLINGHAM, MC ;
THIEBAUT, F ;
GERMANN, UA ;
RUTHERFORD, AV ;
GOTTESMAN, MM ;
BARCA, S ;
TOMBESI, M ;
MORRONE, S ;
SANTONI, A ;
MARIANI, M ;
RAMONI, C ;
DUPUIS, ML ;
CIANFRIGLIA, M .
INTERNATIONAL JOURNAL OF CANCER, 1991, 47 (04) :533-543
[9]   9-ALKYL, MORPHOLINYL ANTHRACYCLINES IN THE CIRCUMVENTION OF MULTIDRUG RESISTANCE [J].
COLEY, HM ;
TWENTYMAN, PR ;
WORKMAN, P .
EUROPEAN JOURNAL OF CANCER, 1990, 26 (06) :665-667
[10]   DRUG-RESISTANCE IN MULTIPLE-MYELOMA AND NON-HODGKINS LYMPHOMA - DETECTION OF P-GLYCOPROTEIN AND POTENTIAL CIRCUMVENTION BY ADDITION OF VERAPAMIL TO CHEMOTHERAPY [J].
DALTON, WS ;
GROGAN, TM ;
MELTZER, PS ;
SCHEPER, RJ ;
DURIE, BGM ;
TAYLOR, CW ;
MILLER, TP ;
SALMON, SE .
JOURNAL OF CLINICAL ONCOLOGY, 1989, 7 (04) :415-424
123