INTERACTIONS BETWEEN CYCLODEXTRINS AND OPHTHALMIC DRUGS

被引：0
|
作者：
VANDOORNE, H
机构：
来源：
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS | 1993年 / 39卷 / 04期
关键词：
CYCLODEXTRINS; OPHTHALMIC DRUGS; ANTIBIOTICS; PRESERVATIVES; STEROIDS; NSAID; INTERACTIONS;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
In this paper the possible applications of cyclodextrins in ophthalmic preparations are reviewed. First, an overview is given of the benefical effects of cyclodextrins, including an increase in solubility, increase in stability, and avoidance of incompatibilities. Then the interaction of cyclodextrin with a number of ophthalmic drugs, including antibiotics, sulfonamides, preservatives, steroids, NSAID and some other compounds, is discussed. It is concluded that cyclodextrins may be useful adjuvants to increase the solubility and stability of ophthalmic drugs, but it remains uncertain whether they have a significant positive effect upon biovailability.
引用
收藏
页码：133 / 139
页数：7
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