DESIGN AND EVALUATION OF BUCCOADHESIVE METOCLOPRAMIDE HYDROGELS COMPOSED OF POLY(ACRYLIC ACID) CROSS-LINKED WITH SUCROSE

被引：20

作者：

GARCIAGONZALEZ, N ^{[1
]}

KELLAWAY, IW ^{[1
]}

BLANCOFUENTE, H ^{[1
]}

ANGUIANOIGEA, S ^{[1
]}

DELGADOCHARRO, B ^{[1
]}

OTEROESPINAR, FJ ^{[1
]}

BLANCOMENDEZ, J ^{[1
]}

机构：

[1] UWCC,WELSH SCH PHARM,DIV PHARMACEUT,CARDIFF,WALES

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1993年 / 100卷 / 1-3期

关键词：

HYDROGEL; METOCLOPRAMIDE; SWELLING; DISSOLUTION; SUCROSE; CARBOPOL; CROSS-LINKING;

D O I：

10.1016/0378-5173(93)90076-R

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We evaluated the effects of polyacrylic acid (PAA) molecular weight and crosslinking agent (sucrose) concentration on swelling and drug (metoclopramide) release characteristics of PAA (Carbopol) hydrogels. Both factors, and the interactions between them, were found to have significant effects on both hydrogel swelling and drug release. In particular, increased sucrose concentration led to reduced swelling and reduced drug release efficiency.

引用

页码：65 / 70

页数：6

共 19 条

[1] EVALUATION OF LAMINATED MUCO-ADHESIVE PATCHES FOR BUCCAL DRUG DELIVERY [J].

ANDERS, R ;

MERKLE, HP .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1989, 49 (03) :231-240

[2] INSULIN PERMEATION THROUGH THERMO-SENSITIVE HYDROGELS [J].

BAE, YH ;

OKANO, T ;

KIM, SW .

JOURNAL OF CONTROLLED RELEASE, 1989, 9 (03) :271-279

[3]

BREMECKER KD, 1989, PHARM IND, V51, P199

[4]

DEVRIES ME, 1989, STP PHARM, V5, P847

[5]

DOELKER E, 1985, FORMES PHARM NOUVELL, P65

[6]

Doelker E, 1986, HYDROGELS MED PHARM, V2, P115

[7]

GRAHAM NB, 1984, BIOMATERIALS, V5, P27, DOI 10.1016/0142-9612(84)90063-2

[8]

HUNT G, 1988, THESIS U WALES WELSH

[9]

KHAN KA, 1972, PHARM ACTA HELV, V47, P594

[10] CONCEPT OF DISSOLUTION EFFICIENCY [J].

KHAN, KA .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1975, 27 (01) :48-49

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