NEW AMPICILLIN DERIVATIVES WITH GLYOXYLOYLBENZHYDRAZONES AS SIDE-CHAINS

被引：0

作者：

HEINISCH, L ^{[1
]}

HANSCHKE, KG ^{[1
]}

WILLITZER, H ^{[1
]}

MOLLMANN, U ^{[1
]}

TRESSELT, D ^{[1
]}

STENGEL, K ^{[1
]}

ECKARDT, K ^{[1
]}

KLEINWACHTER, W ^{[1
]}

机构：

[1] INST MICROBIOL & EXPTL THERAPY,JENA,GERMANY

来源：

PHARMAZIE | 1992年 / 47卷 / 06期

关键词：

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

New ampicillin derivatives were synthesized from glyoxylic acid benzhydrazones by reaction with chloroformates via mixed anhydrides and ampicillin. These compounds were tested in an agar diffusion test against six different bacterial strains and also for their stability against beta-lactamases. Studies about structure-activity relationships have shown, that the activity against different bacterial strains is influenced in different manner by hydrophilic or hydrophobic and electronic properties of substituents.

引用

页码：412 / 415

页数：4