IONIZING-RADIATIONS FROM NUCLEAR ESTABLISHMENTS AND CHILDHOOD LEUKEMIAS - AN ENIGMA

被引:14
作者
EVANS, HJ
机构
[1] MRC Human Genetics Unit, Western General Hospital, Edinburgh, EH4 2XU, Crewe Rd
关键词
D O I
10.1002/bies.950121108
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The Gardner report, recently published in the UK, showing a correlation between incidence of childhood leukaemia and paternal exposure to ionising radiations (amongst fathers working in nuclear power plants) has added a new element to debates about both the risk factors in nuclear power plants and the relationships between ionising radiations and leukaemogenesis. The epidemiologic and genetic evidence concerning leukaemias is reviewed here and it is concluded that the leukaemogenic agent, whose existence is indicated in the Gardner report, is unlikely to be paternal radiation dose per se but rather exposure to another factor that is correlated with paternal radiation dose received. Copyright © 1990 Cambridge University Press
引用
收藏
页码:541 / 549
页数:9
相关论文
共 77 条
  • [1] ACUTE-LEUKEMIA IN 2 GENERATIONS FOLLOWING CHRONIC EXPOSURE TO BENZENE
    AKSOY, M
    ERDEM, S
    ERDOGAN, G
    DINCOL, G
    [J]. HUMAN HEREDITY, 1974, 24 (01) : 70 - 74
  • [2] ANDERSON RC, 1951, AM J DIS CHILD, V81, P312
  • [3] [Anonymous], 1988, SOURCES EFFECTS RISK
  • [4] BARTON CJ, 1985, LANCET, V2, P1248
  • [5] MORTALITY OF EMPLOYEES OF THE UNITED-KINGDOM ATOMIC-ENERGY-AUTHORITY, 1946-1979
    BERAL, V
    INSKIP, H
    FRASER, P
    BOOTH, M
    COLEMAN, D
    ROSE, G
    [J]. BRITISH MEDICAL JOURNAL, 1985, 291 (6493) : 440 - 447
  • [6] Black D, 1984, INVESTIGATION POSSIB
  • [7] INCIDENCE OF LEUKAEMIA AFTER EXPOSURE TO DIAGNOSTIC RADIATION INUTERO
    BROWN, WMC
    DOLL, R
    HILL, AB
    [J]. BRITISH MEDICAL JOURNAL, 1960, 2 (NOV26) : 1539 - 1545
  • [8] BROWN WMC, 1957, HMSO295 SPEC REP
  • [9] A NOVEL ABL PROTEIN EXPRESSED IN PHILADELPHIA-CHROMOSOME POSITIVE ACUTE LYMPHOBLASTIC-LEUKEMIA
    CHAN, LC
    KARHI, KK
    RAYTER, SI
    HEISTERKAMP, N
    ERIDANI, S
    POWLES, R
    LAWLER, SD
    GROFFEN, J
    FOULKES, JG
    GREAVES, MF
    WIEDEMANN, LM
    [J]. NATURE, 1987, 325 (6105) : 635 - 637
  • [10] THE BCL-2 CANDIDATE PROTO-ONCOGENE PRODUCT IS A 24-KILODALTON INTEGRAL-MEMBRANE PROTEIN HIGHLY EXPRESSED IN LYMPHOID-CELL LINES AND LYMPHOMAS CARRYING THE T(14,18) TRANSLOCATION
    CHENLEVY, Z
    NOURSE, J
    CLEARY, ML
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 1989, 9 (02) : 701 - 710