Human Papilloma Virus in Oral Squamous Cell Carcinoma The Enigma Unravelled

被引：5

作者：

Khot, Komal P. ^{[1
]}

Deshmane, Swati D. ^{[1
]}

Choudhari, Sheetal ^{[1
]}

机构：

[1] YMT Dent coll & PG Inst, Dept Oral & Maxillofacial Pathol, Navi Mumbai, India

来源：

CHINESE JOURNAL OF DENTAL RESEARCH | 2016年 / 19卷 / 01期

关键词：

HPV; Koilocytes; Squamous cell carcinoma;

D O I：

10.3290/j.cjdr.a35693

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Squamous cell carcinoma of the head and neck (HNSCC) has long been regarded as a disease entity having a remarkable incidence worldwide and a fairly onerous prognosis; thus encouraging further research on factors that might modify disease outcome. Squamous cell carcinomas encompass at least 90% of all oral malignancies. Several factors like tobacco and tobacco-related products, alcohol, genetic predisposition and hormonal factors are suspected as possible causative factors. Human papilloma virus (HPV), the causal agent of cervical cancer also appears to be involved in the aetiology of oral and oropharyngeal cancer. HPVpositive squamous cell carcinoma (SCC) seems to differ from HPV-negative SCC. Many questions about the natural history of oral HPV infection remain under investigation. The aim of this review is to highlight the current understanding of HPV-associated oral cancer with an emphasis on its prognosis, detection and management.

引用

页码：17 / 23

页数：7

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