ALPHA-RECEPTOR-MEDIATED MODULATION OF H-3-NORADRENALINE RELEASE FROM RAT-BRAIN CORTEX SYNAPTOSOMES

被引：49
作者：
MULDER, AH
LANGEN, CDJD
DEREGT, V
HOGENBOOM, F
机构：
[1] Department of Pharmacology, Free University, Medical Faculty, Amsterdam, 1081-BT
来源：
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY | 1978年 / 303卷 / 02期
关键词：
Cerebral cortex; Noradrenaline release; Presynaptic; α-receptors; Synaptosomes;
D O I：
10.1007/BF00508068
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effects of oxymetazoline and noradrenaline (in the presence of desipramine) on the release of 3H-noradrenaline from rat brain cortex synaptosomes were studied using a superfusion technique. Both drugs (at 1μM concentrations) were found to reduce the depolarization-induced (15 mM K+) release of 3H-noradrenaline. The release-modulating effect of noradrenaline was antagonized by phentolamine and yohimbine. The data provide direct evidence for the hypothesis that α-receptors modulating the release of noradrenaline are localized on varicosities of central noradrenergic neurones. © 1978 Springer-Verlag.
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页码：193 / 196
页数：4
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