TRANSITION STATE ANALOGUES FOR ENZYME CATALYSIS

被引：366
作者：
WOLFENDE.R
机构：
[1] Program in Biochemical Sciences, Princeton University, Princeton
[2] Laboratory of Molecular Biophysics, Dyson Perrins Laboratory
来源：
NATURE | 1969年 / 223卷 / 5207期
关键词：
D O I：
10.1038/223704a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
A method for designing metabolic inhibitors and investigating enzymatic mechanisms at the atomic level. © 1969 Nature Publishing Group.
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页码：704 / &
相关论文
共 14 条
[1]   KINETICS OF TRIOSE PHOSPHATE ISOMERASE [J].
BURTON, PM ;
WALEY, SG .
BIOCHIMICA ET BIOPHYSICA ACTA, 1968, 151 (03) :714-&
[2]   STUDIES OF ENZYMATIC DEAMINATION OF ARA-CYTIDINE .V. INHIBITION IN VITRO AND IN VIVO BY TETRAHYDROURIDINE AND OTHER REDUCED PYRIMIDINE NUCLEOSIDES [J].
CAMIENER, GW .
BIOCHEMICAL PHARMACOLOGY, 1968, 17 (09) :1981-&
[3]   PURIFICATION AND MECHANISM OF ACTION OF PROLINE RACEMASE [J].
CARDINALE, GJ ;
ABELES, RH .
BIOCHEMISTRY, 1968, 7 (11) :3970-+
[4]  
Glasstone S, 1941, THEORY RATE PROCESSE
[5]  
Jencks WP., 1966, CURRENT ASPECTS BIOC, P273
[6]   PRELIMINARY CRYSTALLOGRAPHIC DATA FOR TRIOSE PHOSPHATE ISOMERASE [J].
JOHNSON, LN ;
WALEY, SG .
JOURNAL OF MOLECULAR BIOLOGY, 1967, 29 (02) :321-&
[7]  
NOVOA WB, 1959, J BIOL CHEM, V234, P1143
[8]   NATURE OF FORCES BETWEEN LARGE MOLECULES OF BIOLOGICAL INTEREST [J].
PAULING, L .
NATURE, 1948, 161 (4097) :707-709
[9]  
Pauling L., 1946, CHEM ENG NEWS, V24, p[1375, 1375], DOI DOI 10.1021/CEN-V024N010.P1375
[10]  
PHILLIPS DC, 1967, 7TH P INT C BIOCH TO, P63
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