CALCIUM AND PHOSPHORUS-CONTENT IN BONE TISSUE OF OVARIECTOMIZED RATS WITH A FRACTURE OF THE SHINBONE - EFFECT OF VITAMIN-K AND VITAMIN-D METABOLITES

Calcium and phosphorus content in the bone tissue of ovariectomized rats with a shinbone fracture has been estimated. It was found out.that unlike pseudooperated animals. whose fracture was accompanied by a decrease of calcium and phosphorus content and density in the right proximal epiphysis of the femur, in case of ovariectomized rats those parameters increased. Under those conditions a decrease in the epiphysis density and calcium and phosphorus content both in the shinbone and in the femur of the left extremity was similar both in pseudooperated and ovariectomized rats. Administration of 1-alpha (OH)D3, 24R, 25(OH)2D3 and vitamin K to ovariectomized animals with a shinbone fracture produced no positive effect on the bone tissue, which anyhow, did not exclude a possibility of a positive effect in other doses and for a longer period of time.