THE GENES FOR THE LIPOPOLYSACCHARIDE BINDING-PROTEIN (LBP) AND THE BACTERICIDAL PERMEABILITY INCREASING PROTEIN (BPI) ARE ENCODED IN THE SAME REGION OF HUMAN CHROMOSOME-20

被引：45
作者：
GRAY, PW
CORCORRAN, AE
EDDY, RL
BYERS, MG
SHOWS, TB
机构：
[1] CHARING CROSS SUNLEY MED RES CTR,LONDON W6 8LW,ENGLAND
[2] NEW YORK STATE DEPT HLTH,ROSWELL PK MEM INST,DEPT HUMAN GENET,BUFFALO,NY 14263
来源：
GENOMICS | 1993年 / 15卷 / 01期
关键词：
D O I：
10.1006/geno.1993.1030
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The lipopolysaccharide binding protein is an acute-phase reactant produced during gram-negative bacterial infections. The bactericidal/permeability increasing protein is associated with human neutrophil granules and has bactericidal activity on gram-negative organisms. In addition to their functional relationship, both proteins share extensive structural similarity. This article demonstrates that the genes for both proteins are in the same region of human chromosome 20, between q11.23 and q12. © 1993 by Academic Press, Inc.
引用
收藏
页码：188 / 190
页数：3
相关论文
共 10 条
[1]   NOVEL GENES FOR POTENTIAL LIGAND-BINDING PROTEINS IN SUBREGIONS OF THE OLFACTORY MUCOSA [J].
DEAR, TN ;
BOEHM, T ;
KEVERNE, EB ;
RABBITTS, TH .
EMBO JOURNAL, 1991, 10 (10) :2813-2819
[2]   CLONING AND SEQUENCING OF HUMAN CHOLESTERYL ESTER TRANSFER PROTEIN CDNA [J].
DRAYNA, D ;
JARNAGIN, AS ;
MCLEAN, J ;
HENZEL, W ;
KOHR, W ;
FIELDING, C ;
LAWN, R .
NATURE, 1987, 327 (6123) :632-634
[3]  
GRAY PW, 1989, J BIOL CHEM, V264, P9505
[4]   ASSIGNMENT OF THE PEPSINOGEN GENE-COMPLEX (PGA) TO HUMAN-CHROMOSOME REGION 11Q13 BY INSITU HYBRIDIZATION [J].
NAKAI, H ;
BYERS, MG ;
SHOWS, TB ;
TAGGART, RT .
CYTOGENETICS AND CELL GENETICS, 1986, 43 (3-4) :215-217
[5]  
OOI CE, 1987, J BIOL CHEM, V262, P14891
[6]  
SHOWS TB, 1983, ISOZYMES-CURR T BIOL, V10, P323
[7]  
SHOWS TB, 1982, ADV HUM GENET, V12, P341
[8]  
SHUMANN RR, 1990, SCIENCE, V249, P1429
[9]   ISOLATION OF A LIPOPOLYSACCHARIDE-BINDING ACUTE PHASE REACTANT FROM RABBIT SERUM [J].
TOBIAS, PS ;
SOLDAU, K ;
ULEVITCH, RJ .
JOURNAL OF EXPERIMENTAL MEDICINE, 1986, 164 (03) :777-793
[10]   HIGH-RESOLUTION CHROMOSOMAL LOCALIZATION OF HUMAN GENES FOR AMYLASE, PROOPIOMELANOCORTIN, SOMATOSTATIN, AND A DNA FRAGMENT (D3S1) BY INSITU HYBRIDIZATION [J].
ZABEL, BU ;
NAYLOR, SL ;
SAKAGUCHI, AY ;
BELL, GI ;
SHOWS, TB .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (22) :6932-6936
1