CONFORMATION OF LUTEINIZING-HORMONE-RELEASING HORMONE, NUCLEAR OVERHAUSER OBSERVATIONS

被引：13
作者：
SPRECHER, RF
MOMANY, FA
机构：
[1] Department of Chemistry, Memphis State University, Memphis
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 87卷 / 01期
关键词：
D O I：
10.1016/0006-291X(79)91648-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Observations of proton nuclear Overhauser effects in the molecule Luteinizing Hormone-Releasing Hormone indicate that a high population of a particular set of conformers exists in water solution. The results can be interpreted as two distinct conformers in which the pGlu1 ring is in close proximity to aromatic residues further along the sequence of the linear structure. The observed nuclear Overhauser effects were in agreement with the enhancements calculated from models obtained by conformational energy calculations. © 1979.
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页码：72 / 77
页数：6
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