DESIGN AND USE OF AN APPARATUS FOR MEASURING DIFFUSION THROUGH GLYCEROGELATIN FILMS

被引：4
|
作者：
MORETON, RC [1 ]
ARMSTRONG, NA [1 ]
机构：
[1] UNIV WALES COLL CARDIFF,WELSH SCH PHARM,CARDIFF CF1 3XF,S GLAM,WALES
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1995年 / 122卷 / 1-2期
关键词：
GLYCEROGELATIN; ETHANOL DIFFUSION; MOISTURE CONTENT; SOFT GELATIN FILM;
D O I：
10.1016/0378-5173(95)00042-H
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The diffusion of ethanol into and through soft gelatin films analogous to capsule shell formulations during the drying process has been investigated using a specially designed diffusion cell. Using microcomputer-controlled sampling, it was possible to monitor the diffusion through films at regular intervals for periods of 24 h and longer. Films having moisture contents in the range 4.5-42% w/w were investigated. The moisture content of the glycerogelatin soft gelatin capsule shell formulations has an important influence on the diffusion process; the higher the moisture content, the more rapid the diffusion of ethanol.
引用
收藏
页码：79 / 89
页数：11
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