COMPARISON OF PATIENT-CONTROLLED ANALGESIA IN CHILDREN BY IV AND SC ROUTES OF ADMINISTRATION

Sixty children undergoing appendicectomy were allocated randomly to receive one of two PCA regimens with morphine. Group IV received standard iv. PCA with a bolus dose of morphine 20 mu g kg(-1) and a background infusion of 4 mu g kg(-1) h(-1) while group SC received PCA by the s.c. route with a bolus dose of morphine 20 mu g kg(-1) and a background infusion of 5 mu g kg(-1) h(-1). in both groups there was a lockout interval of 5 min. Group SC self-administered significantly less morphine (P < 0.05) and had a significantly (P < 0.09) greater percentage of valid demands for analgesia than group IV. There were no differences in pain scores between the groups at rest or during movement. Group IV suffered significantly (P < 0.01) more hypoxic episodes than group SC. There were no differences between groups in the incidence of postoperative nausea and vomiting or oversedation. S.c. PCA appears to be as effective and safe as iv. PCA. By giving patients feedback on the occurrence of valid demands for analgesia, s.c. PCA may produce more appropriate and effective use of PCA.