CLINICAL UTILITY OF UNBOUND ANTIEPILEPTIC DRUG BLOOD-LEVELS IN THE MANAGEMENT OF EPILEPSY

被引：42

作者：

LENN, NJ ^{[1
]}

ROBERTSON, M ^{[1
]}

机构：

[1] UNIV VIRGINIA,MED CTR,SCH MED,DEPT NEUROL,CHARLOTTESVILLE,VA 22901

来源：

NEUROLOGY | 1992年 / 42卷 / 05期

关键词：

D O I：

10.1212/WNL.42.5.988

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We tabulated all unbound and total antiepileptic blood levels collected in 13 months. According to strict criteria, 24% of phenytoin and 15% of valproate unbound blood levels but none of the carbamazepine unbound levels had clinical significance in the management of seizures or side effects. These data support frequent use of unbound phenytoin or valproate blood levels in the management of epilepsy.

引用

页码：988 / 990

页数：3

共 15 条

[1] TOTAL AND FREE SERUM CONCENTRATIONS OF CARBAMAZEPINE AND CARBAMAZEPINE-10,11-EPOXIDE IN CHILDREN WITH EPILEPSY [J].

AGBATO, OA ;

ELYAS, AA ;

PATSALOS, PN ;

BRETT, EM ;

LASCELLES, PT .

ARCHIVES OF NEUROLOGY, 1986, 43 (11) :1111-1116

[2] CARBAMAZEPINE INCREASES PHENYTOIN SERUM CONCENTRATION AND REDUCES PHENYTOIN CLEARANCE [J].

BROWNE, TR ;

SZABO, GK ;

EVANS, JE ;

EVANS, BA ;

GREENBLATT, DJ .

NEUROLOGY, 1988, 38 (07) :1146-1150

[3] VARIABLE FREE AND TOTAL VALPROIC ACID CONCENTRATIONS IN SOLE-DRUG AND MULTIDRUG THERAPY [J].

CRAMER, JA ;

MATTSON, RH ;

BENNETT, DM ;

SWICK, CT .

THERAPEUTIC DRUG MONITORING, 1986, 8 (04) :411-415

[4] PLASMA-CONCENTRATIONS OF UNBOUND PHENYTOIN IN THE MANAGEMENT OF EPILEPSY [J].

KILPATRICK, CJ ;

WANWIMOLRUK, S ;

WING, LMH .

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1984, 17 (05) :539-546

[5]

LEVY G, 1976, EFFECT DISEASE STATE, P137

[6] MONITORING OF FREE DRUG LEVELS - DETERMINATION OF FREE CONCENTRATION VERSUS FREE FRACTION [J].

LEVY, RH .

THERAPEUTIC DRUG MONITORING, 1983, 5 (03) :243-244

[7] MONITORING OF FREE VALPROIC ACID LEVELS [J].

LEVY, RH .

THERAPEUTIC DRUG MONITORING, 1980, 2 (02) :199-201

[8]

LEVY RH, 1985, EPILEPSIA S1, V26, P552

[9] PLASMA-PROTEIN BINDING OF PHENYTOIN IN 100 EPILEPTIC PATIENTS [J].

PETERSON, GM ;

MCLEAN, S ;

ALDOUS, S ;

VONWITT, RJ ;

MILLINGEN, KS .

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1982, 14 (02) :298-300

[10]

PORTER RJ, 1989, ANTIEPILEPTIC DRUGS, P117

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