EFFECT OF HYPOPHYSECTOMY AND GROWTH-HORMONE ADMINISTRATION ON SOMATOSTATIN CONTENT IN THE RAT HYPOTHALAMUS

被引：54
作者：
KANATSUKA, A
MAKINO, H
MATSUSHIMA, Y
OSEGAWA, M
YAMAMOTO, M
KUMAGAI, A
机构：
[1] Second Department of Internal Medicine, Chiba University, School of Medicine, Chiba
来源：
NEUROENDOCRINOLOGY | 1979年 / 29卷 / 03期
关键词：
Bovine growth hormone; Hypophysectomy; Hypothalamus; Somatostatin;
D O I：
10.1159/000122921
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The effect of hypophysectomy and bovine GH administration on somatostatin (SRIF) content in the rat hypothalamus was investigated. SRIF content was determined by a specific radioimmunoassay method described elsewhere. The total SRIF content of the rat hypothalamus as well as its content per milligram wet weight had decreased 4 weeks after hypophysectomy but was restored significantly in those rats which were subjected to bovine GH administration for 7 days 3 weeks after hypophysectomy. Furthermore, in nonoperated rats, increase of hypothalamic SRIF content was observed after 7 days GH administration. These results indicate that growth hormone may influence the SRIF content of hypothalamus and it seems likely that a feedback mechanism between pituitary GH and hypothalamic SRIF exists. © 1979 S. Karger AG, Basel.
引用
收藏
页码：186 / 190
页数：5
相关论文
共 14 条
[1]   SOMATOSTATINERGIC NEURONS IN ANTERIOR HYPOTHALAMUS - IMMUNOHISTOCHEMICAL LOCALIZATION [J].
ALPERT, LC ;
BRAWER, JR ;
PATEL, YC ;
REICHLIN, S .
ENDOCRINOLOGY, 1976, 98 (01) :255-258
[2]  
ARIMURA A, 1975, P SOC EXP BIOL MED, V148, P784
[3]  
BAKER BL, 1976, P SOC EXP BIOL MED, V151, P599
[4]   HYPOTHALAMIC POLYPEPTIDE THAT INHIBITS SECRETION OF IMMUNOREACTIVE PITUITARY GROWTH-HORMONE [J].
BRAZEAU, P ;
VALE, W ;
BURGUS, R ;
LING, N ;
BUTCHER, M ;
RIVIER, J ;
GUILLEMIN, R .
SCIENCE, 1973, 179 (4068) :77-79
[5]   REGIONAL DISTRIBUTION OF SOMATOSTATIN IN RAT-BRAIN [J].
BROWNSTEIN, M ;
ARIMURA, A ;
SATO, H ;
SCHALLY, AV ;
KIZER, JS .
ENDOCRINOLOGY, 1975, 96 (06) :1456-1461
[6]   EFFECT OF HYPOTHALAMIC DEAFFERENTATION ON SOMATOSTATIN-LIKE ACTIVITY IN RAT-BRAIN [J].
BROWNSTEIN, MJ ;
ARIMURA, A ;
FERNANDEZDURAGO, R ;
SCHALLY, AV ;
PALKOVITS, M ;
KIZER, JS .
ENDOCRINOLOGY, 1977, 100 (01) :246-249
[7]  
HALL R, 1973, LANCET, V2, P581
[8]   IMMUNOHISTOCHEMICAL LOCALIZATION OF SOMATOSTATIN (GROWTH-HORMONE RELEASE-INHIBITING FACTOR) IN GUINEA-PIG BRAIN [J].
HOKFELT, T ;
EFENDIC, S ;
JOHANSSO.O ;
LUFT, R ;
ARIMURA, A .
BRAIN RESEARCH, 1974, 80 (01) :165-169
[9]  
MAKINO H, 1977, ENDOCR JAP, V24, P293
[10]   ELECTRON-MICROSCOPIC IMMUNOHISTOCHEMICAL LOCALIZATION OF GROWTH HORMONE-RELEASE INHIBITING HORMONE (SOMATOSTATIN) IN RAT MEDIAN-EMINENCE [J].
PELLETIER, G ;
LABRIE, F ;
ARIMURA, A ;
SCHALLY, AV .
AMERICAN JOURNAL OF ANATOMY, 1974, 140 (03) :445-450
12