IODOMETRIC SOLID-SPECTROPHOTOMETRIC DETERMINATION OF CAPTOPRIL IN PHARMACEUTICAL DRUGS

被引：0
作者：
Trokhimenko, A. Yu. [1 ]
Zaporozhets, O. A. [1 ]
机构：
[1] Kyiv Natl Taras Shevchenko Univ, Dept Analyt Chem, Kiev, Ukraine
来源：
IZVESTIYA VYSSHIKH UCHEBNYKH ZAVEDENII KHIMIYA I KHIMICHESKAYA TEKHNOLOGIYA | 2014年 / 57卷 / 07期
关键词：
iodinemetry; solid phase spectrophotometry; captopril; polyurethane foam;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The method for solid-iodometric spectrophotometric determination of captopril in pharmaceutical preparations was proposed. Captopril is oxidized by iodine. Excess of iodine is extracted on to polyurethane foam and spectrophotometric is detected on the surface of the sorbent. The linearity of the calibration curve is observed up to a concentration of captopril of 40 m mu mol/l. Detection limit, calculated by 3 sigma-criterion, is 0.9 m mu mol/l. Filling substances in quantities exceeding their content in the drug formulations of captopril does not affect on the determination.
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页码：37 / +
页数：5
相关论文
共 16 条
  • [1] ABBAS MN, 1989, ANAL LETT, V22, P1555
  • [2] [Anonymous], 2001, EUROPEAN PHARMACOPOE
  • [3] [Anonymous], 2007, STATE PHARMACOPOEIA
  • [4] Brykina G. D., 1988, J ANAL KHIM, V43, P1547
  • [5] BRYKINA GD, 1995, J ANAL CHEM+, V50, P440
  • [6] Ciesielski W, 2006, CHEM ANAL-WARSAW, V51, P653
  • [7] Dmitrienko S. G., 2010, POLYURETHANES SORPTI
  • [8] Sensitive determination of captopril by flow injection analysis with chemiluminescence detection based on the enhancement of the luminol reaction
    Economou, A
    Themelis, DG
    Theodoridis, G
    Tzanavaras, PD
    [J]. ANALYTICA CHIMICA ACTA, 2002, 463 (02) : 249 - 255
  • [9] Ivanov V.M., 2001, RUSS CHEM REV+, V70, P357, DOI [10.1070/RC2001v070n05ABEH000636, DOI 10.1070/RC2001V070N05ABEH000636]
  • [10] Ksenzenko V. I., 1995, CHEM TECHNOLOGY BROM
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