MODERATE CYTOTOXICITY OF PROANTHOCYANIDINS TO HUMAN TUMOR-CELL LINES

被引：44
|
作者：
KOLODZIEJ, H
HABERLAND, C
WOERDENBAG, HJ
KONINGS, AWT
机构：
[1] UNIV GRONINGEN,CTR PHARM,DEPT PHARMACEUT BIOL,9713 AW GRONINGEN,NETHERLANDS
[2] UNIV GRONINGEN,FAC MED,DEPT RADIOBIOL,9713 BZ GRONINGEN,NETHERLANDS
来源：
PHYTOTHERAPY RESEARCH | 1995年 / 9卷 / 06期
关键词：
CYTOTOXICITY; HUMAN TUMOR CELL LINES; POLYPHENOLS; PROANTHOCYANIDINS; STRUCTURE-ACTIVITY RELATIONSHIPS;
D O I：
10.1002/ptr.2650090605
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
In the present study the cytotoxicity of 16 proanthocyanidins was evaluated in GLC(4), a human small cell lung carcinoma cell line, and in COLO 320, a human colorectal cancer cell line, using the microculture tetrazolium (MTT) assay. With IC50 values ranging from 18 to >200 mu m following continuous incubation, the proanthocyanidins examined possess only moderate to low cytotoxicity. The highest cytotoxicity was found in a series of galloylated proanthocyanidins. An increase in the number of galloyl substituents increased cytotoxicity. Simple proanthocyanidins possess low cytotoxicity, that was independent of the stereochemistry. Compounds with doubly linked units had negligible cytotoxic effects, even at 200 mu m, the highest concentration tested.
引用
收藏
页码：410 / 415
页数：6
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