PROLONGED SHEDDING OF AMANTADINE-RESISTANT INFLUENZA-A VIRUSES BY IMMUNODEFICIENT PATIENTS - DETECTION BY POLYMERASE CHAIN-REACTION - RESTRICTION ANALYSIS

被引：127
作者：
KLIMOV, AI
ROCHA, E
HAYDEN, FG
SHULT, PA
ROUMILLAT, LF
COX, NJ
机构：
[1] CTR DIS CONTROL & PREVENT,INFLUENZA BRANCH,ATLANTA,GA 30333
[2] UNIV VIRGINIA,SCH MED,DEPT INTERNAL MED,CHARLOTTESVILLE,VA 22908
[3] UNIV VIRGINIA,SCH MED,DEPT PATHOL,CHARLOTTESVILLE,VA 22908
[4] UNIV WISCONSIN,WISCONSIN STATE LAB HYG,MADISON,WI 53706
来源：
JOURNAL OF INFECTIOUS DISEASES | 1995年 / 172卷 / 05期
关键词：
D O I：
10.1093/infdis/172.5.1352
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Consecutive A (H3N2) influenza virus isolates from 2 influenza virus-infected immunodeficient patients treated with amantadine were examined using a novel polymerase chain reaction (PCR)-restriction analysis for resistance to this antiviral compound. The data indicate that immunodeficient patients may shed resistant viruses for prolonged periods and with different drug resistance mutations present at different times. This PCR-restriction technique allows rapid detection of amantadine- or rimantadine-resistant strains.
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页码：1352 / 1355
页数：4
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