SELECTIVITY AND MECHANISM IN THE MICROSOMAL BENZYLIC HYDROXYLATION

被引：10

作者：

AMODEO, R ^{[1
]}

BACIOCCHI, E ^{[1
]}

CRESCENZI, M ^{[1
]}

LANZALUNGA, O ^{[1
]}

机构：

[1] UNIV ROMA LA SAPIENZA,DEPARTIMENTO CHIM,I-00185 ROME,ITALY

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 24期

关键词：

D O I：

10.1016/S0040-4039(00)97427-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The oxidation by rat liver microsomes of 4-Z-1,2-dimethylbenzenes (1) and 4-methoxybenzyltrimethylsilane (2) has been investigated. The reaction of the former substrates leads to the expected isomeric benzyl alcohols 3 and 4, with a very low intramolecular selectivity, and only O-demethylation is observed in the reaction of 2. These results suggest the operation of a hydrogen atom transfer mechanism. © 1990.

引用

页码：3477 / 3480

页数：4

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