RRR-ALPHA-TOCOPHERYL SUCCINATE INHIBITS PROLIFERATION AND ENHANCES SECRETION OF TRANSFORMING GROWTH-FACTOR-BETA (TGF-BETA) BY HUMAN BREAST-CANCER CELLS

被引：71
|
作者：
CHARPENTIER, A [1 ]
GROVES, S [1 ]
SIMMONSMENCHACA, M [1 ]
TURLEY, J [1 ]
ZHAO, BH [1 ]
SANDERS, BG [1 ]
KLINE, K [1 ]
机构：
[1] UNIV TEXAS,DEPT ZOOL,AUSTIN,TX 78712
来源：
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL | 1993年 / 19卷 / 03期
关键词：
D O I：
10.1080/01635589309514254
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The RRR-alpha-tocopheryl succinate form of vitamin E inhibits the proliferation of estrogen receptor-positive and estrogen receptor-negative human breast cancer cell lines in a dose-dependent manner in vitro. Analyses of cell-conditioned medium from RRR-alpha-tocopheryl succinate growth-inhibited cells revealed the presence of a potent antiproliferative activity. Characterization of the antiproliferative activity as transforming growth factor-beta (TGF-beta) was established by 1) growth inhibition of the TGF-beta-responsive Mv1Lu-CCL-64 mink lung and murine CTLL-2 cell lines, 2) combination of physical characteristics including heat stability, acid stability, and Bio-Gel P-60 column chromatography elution profile, and 3) neutralization of the antiproliferative activity in the conditioned media by antibodies specific for TGF-beta.
引用
收藏
页码：225 / 239
页数：15
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