BENZODIAZEPINE RECEPTOR MEDIATION OF BEHAVIORAL-EFFECTS OF NITROUS-OXIDE IN MICE

被引：27

作者：

QUOCK, RM

EMMANOUIL, DE

VAUGHN, LK

PRUHS, RJ

机构：

[1] MARQUETTE UNIV,SCH DENT,DEPT PEDIAT DENT,MILWAUKEE,WI 53233

[2] MARQUETTE UNIV,SCH DENT,DEPT BASIC SCI,MILWAUKEE,WI 53233

来源：

PSYCHOPHARMACOLOGY | 1992年 / 107卷 / 2-3期

关键词：

NITROUS OXIDE; CHLORDIAZEPOXIDE; FLUMAZENIL; NALOXONE; BENZODIAZEPINE RECEPTORS; STAIRCASE TEST; MOUSE;

D O I：

10.1007/BF02245153

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Nitrous oxide produces behavioral effects, the underlying mechanism of which is not known. In the mouse staircase test, exposure to nitrous oxide caused a reduction in rearing activity, an effect similar to that produced by benzodiazepines in this paradigm, when its opioid action on locomotion is blocked by naloxone. In this study, we tested whether effects of nitrous oxide might be mediated by benzodiazepine receptors, using chlordiazepoxide as a control. The abilities of nitrous oxide and chlordiazepoxide to reduce rearing were significantly attenuated in mice pretreated with the benzodiazepine receptor blocker flumazenil or rendered tolerant to benzodiazepines. These findings suggest an involvement of benzodiazepine receptors in mediation of certain behavioral effects of nitrous oxide.

引用

页码：310 / 314

页数：5

共 41 条

[1]

ALLEN GD, 1984, DENTAL ANESTHESIA AN

[2]

ALLEN GD, 1979, POSTGRADUATE DENTAL, V1

[3]

[Anonymous], 1985, NITROUS OXIDE N2O, DOI DOI 10.1097/00004669-198504000-00009

[4] RELATIONSHIP BETWEEN NITROUS-OXIDE CONSCIOUS SEDATION AND THE HYPNOTIC STATE [J].