ACTIVATION MARKERS ON PERIPHERAL-BLOOD T-CELLS FROM PATIENTS WITH ACTIVE OR INACTIVE SYSTEMIC LUPUS-ERYTHEMATOSUS - CORRELATION WITH PROLIFERATIVE RESPONSES AND PRODUCTION OF IL-2

被引:24
作者
ALCOCERVARELA, J
ALARCONRIQUELME, M
LAFFON, A
SANCHEZMADRID, F
ALARCONSEGOVIA, D
机构
[1] INST NACL NUTR SALVADOR ZUBIRAN,DEPT IMMUNOL & RHEUMATOL,VASCO QUIROGA 15,DELEGAC TLALPAN,MEXICO CITY 14000,DF,MEXICO
[2] HOSP PRINCESA,RHEUMATOL SECT,MADRID,SPAIN
[3] HOSP PRINCESA,IMMUNOL SECT,MADRID,SPAIN
关键词
D O I
10.1016/0896-8411(91)90056-I
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Using various monoclonal antibodies to T cell activation molecules it has been shown that purified T cells from patients with active systemic lupus erythematosus overexpress the 4F2, IL-2R (CD25), HLA-DR and T10 antigens. T cells from patients with inactive disease had increased expression of VLA-1 and HLA-DR. Increased T10 expression on T cells from patients with active disease correlated inversely with the production of IL-2, whereas expression of CD25 was slightly increased after 3-day culture with either PHA or anti-CD3. These results provide further evidence of the in vivo activation of T cells in SLE and suggest that such activation comes slowly to a halt upon disease remission. © 1991.
引用
收藏
页码:935 / 945
页数:11
相关论文
共 22 条
[1]  
ALARCONSEGOVIA D, 1985, CLIN RHEUM DIS, V11, P451
[2]  
ALARCONSEGOVIA D, 1982, ARTHRITIS RHEUM, V23, P304
[3]   DECREASED PRODUCTION OF AND RESPONSE TO INTERLEUKIN-2 BY CULTURED LYMPHOCYTES FROM PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS [J].
ALCOCERVARELA, J ;
ALARCONSEGOVIA, D .
JOURNAL OF CLINICAL INVESTIGATION, 1982, 69 (06) :1388-1392
[4]  
ALCOCERVARELA J, 1989, CLIN EXP IMMUNOL, V77, P319
[5]   INVOLVEMENT OF THE CD4 MOLECULE IN A POST-ACTIVATION EVENT ON T-CELL PROLIFERATION [J].
CARRERA, AC ;
SANCHEZMADRID, F ;
LOPEZBOTET, M ;
BERNABEU, C ;
DELANDAZURI, MO .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1987, 17 (02) :179-186
[6]   CONTINGENT GENETIC REGULATORY EVENTS IN LYMPHOCYTE-T ACTIVATION [J].
CRABTREE, GR .
SCIENCE, 1989, 243 (4889) :355-361
[7]   ISOLATION AND STRUCTURAL CHARACTERIZATION OF THE HUMAN 4F2 HEAVY-CHAIN GENE, AN INDUCIBLE GENE INVOLVED IN LYMPHOCYTE-T ACTIVATION [J].
GOTTESDIENER, KM ;
KARPINSKI, BA ;
LINDSTEN, T ;
STROMINGER, JL ;
JONES, NH ;
THOMPSON, CB ;
LEIDEN, JM .
MOLECULAR AND CELLULAR BIOLOGY, 1988, 8 (09) :3809-3819
[8]   VLA-1 - A T-CELL SURFACE-ANTIGEN WHICH DEFINES A NOVEL LATE STAGE OF HUMAN T-CELL ACTIVATION [J].
HEMLER, ME ;
JACOBSON, JG ;
BRENNER, MB ;
MANN, D ;
STROMINGER, JL .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1985, 15 (05) :502-508
[9]   HLA-DP+ T-CELLS AND DEFICIENT INTERLEUKIN-2 PRODUCTION IN PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS [J].
HISHIKAWA, T ;
TOKANO, Y ;
SEKIGAWA, I ;
ANDO, S ;
TAKASAKI, Y ;
HASHIMOTO, H ;
HIROSE, S ;
OKUMURA, K ;
ABE, M ;
SHIRAI, T .
CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 1990, 55 (02) :285-296
[10]  
HUANG YP, 1986, J IMMUNOL, V137, P3515