SOLUBILITIES OF LOWER TESTOSTERONE ESTERS

被引：32

作者：

JAMES, KC

ROBERTS, M

机构：

[1] Welsh School of Pharmacy, Institute of Science and Technology, University of Wales, Cardiff, Cathays Park

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1968年 / 20卷 / 09期

关键词：

D O I：

10.1111/j.2042-7158.1968.tb09842.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The solubilities of the formate to valerate esters of testosterone have been determined in water and several organic solvents. The aqueous solubilities decrease logarithmically as the homologous series is ascended, but the acetate is less soluble than anticipated in the organic solvents. The variation in solubility from ester to ester can be predicted in the organic solvents from thermodynamic data, and is a reflection of the differences in melting point. The melting point differences are explained from the space group dimensions and the area of α to α face contact in the crystals. 1968 Royal Pharmaceutical Society of Great Britain

引用

页码：709 / &

共 11 条

[1] The solubility of non-electrolytes. Part II. The influence of the polar group on the free energy of hydration of aliphatic compounds. [J].