SYNTHETIC STUDIES ON THE FURAN RING OF WORTMANNIN

被引：26

作者：

NORMAN, BH

PASCHAL, J

VLAHOS, CJ

机构：

[1] Cancer Research, Eli Lilly and Company, Lilly Corporate Center, Indianapolis

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 11期

关键词：

D O I：

10.1016/0960-894X(95)00191-U

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Synthetic studies on the fungal metabolite, wortmannin, were undertaken in an effort to gain insight into the structure activity relationships of wortmannin analogs on phosphatidylinositol-3'-kinase (PI-3-kinase). Our work has focused on the chemistry of the previously unexplored furan ring and has uncovered several interesting and novel chemical transformations, which are described herein.

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页码：1183 / 1186

页数：4

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