REDUCTIVE ALKYLATION OF 9-AMINO-XANTHEN-3-YLOXYMETHYLPOLY(STYRENE) - A NOVEL PROCEDURE FOR THE SYNTHESIS OF PEPTIDYL N-ALKYL AMIDES BY FMOC/BU(T) CHEMISTRY

被引：30

作者：

CHAN, WC

MELLOR, SL

机构：

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1995年 / 14期

关键词：

D O I：

10.1039/c39950001475

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Reductive N-alkylation of the 'amide' anchor resin, 9-amino-xanthen-3-yloxymethyl poly(styrene) 1, by sequential treatment with alkyl aldehydes under mild acidic conditions followed by NaBH4 in MeOH-DMF, and then followed by optimised Fmoc/Bu(t) solid-phase peptide synthetic procedures afforded an unique class of peptidyl N-alkyl amides in excellent yields.

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页码：1475 / 1477

页数：3

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