STIMULATION OF MEGAKARYOCYTOPOIESIS AND THROMBOPOIESIS BY THE C-MPL LIGAND

被引：1188

作者：

DESAUVAGE, FJ

HASS, PE

SPENCER, SD

MALLOY, BE

GURNEY, AL

SPENCER, SA

DARBONNE, WC

HENZEL, WJ

WONG, SC

KUANG, WJ

OLES, KJ

HULTGREN, B

SOLBERG, LA

GOEDDEL, DV

EATON, DL

机构：

[1] MAYO CLIN, DIV HEMATOL ONCOL, JACKSONVILLE, FL 32224 USA

[2] GENENTECH INC, DEPT MOLEC BIOL, San Francisco, CA 94080 USA

[3] GENENTECH INC, DEPT CARDIOVASC RES, San Francisco, CA 94080 USA

[4] GENENTECH INC, DEPT PROT CHEM, San Francisco, CA 94080 USA

[5] MAYO CLIN & MAYO FDN, DIV HEMATOL ONCOL, ROCHESTER, MN 55905 USA

来源：

NATURE | 1994年 / 369卷 / 6481期

关键词：

D O I：

10.1038/369533a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Physiological platelet synthesis is thought to require the humoral activities of meg-CSF and thrombopoietin, which respectively promote proliferation and maturation of megakaryocytic cells. A meg-CSF/thrombopoietin-like protein that is present in plasma of irradiated pigs has been purified and cloned. This protein binds to and activates the c-mpl protein, a member of the cytokine receptor superfamily. The isolated Mpl ligand shares homology with erythropoietin and stimulates both megakaryocytopoiesis and thrombopoiesis.

引用

页码：533 / 538

页数：6

共 48 条

[11]

HARRINGTON MG, 1990, METHOD ENZYMOL, V182, P488

[12] REGULATION OF HUMAN MEGAKARYOCYTOPOIESIS - ANALYSIS OF PROLIFERATION, PLOIDY AND MATURATION IN LIQUID CULTURES [J].