NITRIC-OXIDE MODULATES ENDOGENOUS DOPAMINE RELEASE IN BOVINE RETINA

被引：87

作者：

BUGNON, O

SCHAAD, NC

SCHORDERET, M

机构：

[1] UNIV GENEVA, MED CTR, DEPT PHARMACOL, CH-1211 GENEVA 4, SWITZERLAND

[2] UNIV CHENE BOURG, INST PSYCHIAT, DIV CLIN PSYCHOPHARMACOL, CH-1225 CHENE BOURG, SWITZERLAND

来源：

NEUROREPORT | 1994年 / 5卷 / 04期

关键词：

DOPAMINE RELEASE; NITRIC OXIDE; CGMP; RETINA;

D O I：

10.1097/00001756-199401120-00007

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A STUDY of the possible modulation by nitric oxide (NO) of endogenous dopamine (DA) release was performed in bovine retina in vitro. NO synthase activity was measured in retinal homogenates and totally blocked by L-nitroarginine methyl ester (L-NA). Intact retinas were also exposed to hydroxylamine, an NO-generator which significantly decreased both basal and potassium-induced liberation of DA. In contrast, dibutyryl cGMP was ineffective. Furthermore, L-NA was able to increase basal DA release, its effects being potentiated in calcium free medium. Taken together, these results suggest that endogenous NO regulates DA release via cGMP independent mechanisms.

引用

页码：401 / 404

页数：4

共 25 条

[1] POSSIBLE INVOLVEMENT OF NITRIC-OXIDE IN LONG-TERM POTENTIATION [J].