DETECTION OF CALBINDIN-D IMMUNOREACTIVITY IN HUMAN FOLLICULAR DENDRITIC CELLS

被引：6
作者：
CHILOSI, M
DOGLIONI, C
PELOSIO, P
MOMBELLO, A
MONTAGNA, L
BENEDETTI, A
LESTANI, M
GIOVANNI, P
MENESTRINA, F
机构：
[1] UNIV VERONA,CATTEDRA EMATOL,I-37134 VERONA,ITALY
[2] OSPED FELTRE,FELTRE,ITALY
来源：
JOURNAL OF PATHOLOGY | 1992年 / 166卷 / 02期
关键词：
FOLLICULAR DENDRITIC CELLS; CALBINDIN-D; IMMUNOHISTOCHEMISTRY;
D O I：
10.1002/path.1711660207
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The calcium-binding protein calbindin-D (28 kD) has been analysed immunohistochemically in different human lymphoid tissues. Combined immunohistochemical staining showed that calbindin-D (28 kD) is expressed by only a proportion of dendritic cells within the light zone of germinal centres, where antigens in the form of immune complexes are trapped and presented to B lymphocytes. All other cell types including macrophages, interdigitating cells, and various lymphocyte populations were negative. The expression of calbindin-D in this functionally relevant subset of follicular dendritic cells could have a role in the regulation of proliferation and selection of memory B-cells by modulating the concentration of calcium ions. Calbindin-D may be a useful marker for analysing in situ the phases of follicular development in different physiological and pathological conditions.
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页码：121 / 127
页数：7
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