QUINOLONE RESISTANCE-DETERMINING REGION IN THE DNA GYRASE GYRB GENE OF ESCHERICHIA-COLI

被引：296
作者：
YOSHIDA, H
BOGAKI, M
NAKAMURA, M
YAMANAKA, LM
NAKAMURA, S
机构：
[1] Research Laboratories, Dainippon Pharm. Co., Ltd., Suita, Osaka 564
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1991年 / 35卷 / 08期
关键词：
D O I：
10.1128/AAC.35.8.1647
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Thirteen spontaneous quinolone-resistant gyrB mutants of Escherichia coli KL16, including two that were examined previously, were divided into two types according to their quinolone resistance patterns. Type 1 mutants were resistant to all the quinolones tested, while type 2 mutants were resistant to acidic quinolones and were hypersusceptible to amphoteric quinolones. Nucleotide sequence analysis disclosed that all nine type 1 mutants had a point mutantion from aspartic acid to asparagine at amino acid 426 and that all four type 2 mutants had a point mutation from lysine to glutamic acid at amino acid 447.
引用
收藏
页码：1647 / 1650
页数：4
相关论文
共 36 条
[1]   SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF NEW ARYLFLUORONAPHTHYRIDINE ANTIBACTERIAL AGENTS [J].
CHU, DTW ;
FERNANDES, PB ;
CLAIBORNE, AK ;
GRACEY, EH ;
PERNET, AG .
JOURNAL OF MEDICINAL CHEMISTRY, 1986, 29 (11) :2363-2369
[2]   NATURE OF TRANSFORMATION PROCESS IN ESCHERICHIA-COLI K12 [J].
COSLOY, SD ;
OISHI, M .
MOLECULAR AND GENERAL GENETICS, 1973, 124 (01) :1-10
[3]   NALIDIXIC-ACID RESISTANCE - 2ND GENETIC CHARACTER INVOLVED IN DNA GYRASE ACTIVITY [J].
GELLERT, M ;
MIZUUCHI, K ;
ODEA, MH ;
ITOH, T ;
TOMIZAWA, JI .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (11) :4772-4776
[4]   DNA TOPOISOMERASES [J].
GELLERT, M .
ANNUAL REVIEW OF BIOCHEMISTRY, 1981, 50 :879-910
[5]  
GROHE K, 1987, LIEBIGS ANN CHEM, P29
[6]  
HAYAKAWA I, 1984, CHEM PHARM BULL, V32, P4907
[7]   PURIFICATION OF SUBUNITS OF ESCHERICHIA-COLI DNA GYRASE AND RECONSTITUTION OF ENZYMATIC-ACTIVITY [J].
HIGGINS, NP ;
PEEBLES, CL ;
SUGINO, A ;
COZZARELLI, NR .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1978, 75 (04) :1773-1777
[8]   A RAPID BOILING METHOD FOR THE PREPARATION OF BACTERIAL PLASMIDS [J].
HOLMES, DS ;
QUIGLEY, M .
ANALYTICAL BIOCHEMISTRY, 1981, 114 (01) :193-197
[9]   PREDICTION OF PROTEIN ANTIGENIC DETERMINANTS FROM AMINO-ACID-SEQUENCES [J].
HOPP, TP ;
WOODS, KR .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (06) :3824-3828
[10]   QUINOLONE ANTIBACTERIAL AGENTS . OXOLINIC ACID AND RELATED COMPOUNDS [J].
KAMINSKY, D ;
MELTZER, RI .
JOURNAL OF MEDICINAL CHEMISTRY, 1968, 11 (01) :160-&
1234