QUINOLONE RESISTANCE-DETERMINING REGION IN THE DNA GYRASE GYRB GENE OF ESCHERICHIA-COLI

被引：294
|
作者：
YOSHIDA, H
BOGAKI, M
NAKAMURA, M
YAMANAKA, LM
NAKAMURA, S
机构：
[1] Research Laboratories, Dainippon Pharm. Co., Ltd., Suita, Osaka 564
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1991年 / 35卷 / 08期
关键词：
D O I：
10.1128/AAC.35.8.1647
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Thirteen spontaneous quinolone-resistant gyrB mutants of Escherichia coli KL16, including two that were examined previously, were divided into two types according to their quinolone resistance patterns. Type 1 mutants were resistant to all the quinolones tested, while type 2 mutants were resistant to acidic quinolones and were hypersusceptible to amphoteric quinolones. Nucleotide sequence analysis disclosed that all nine type 1 mutants had a point mutantion from aspartic acid to asparagine at amino acid 426 and that all four type 2 mutants had a point mutation from lysine to glutamic acid at amino acid 447.
引用
收藏
页码：1647 / 1650
页数：4
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