OXIDATION OF CHOLESTEROL BY HYDROXYL RADICAL

被引：29

作者：

ANSARI, GAS

SMITH, LL

机构：

[1] Division of Biochemistry, Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas

来源：

PHOTOCHEMISTRY AND PHOTOBIOLOGY | 1979年 / 30卷 / 01期

关键词：

D O I：

10.1111/j.1751-1097.1979.tb07127.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Abstract— The oxidation of chblesterol by hydroxyl radical generated by 60Co y‐radiolysis of aqueous cholesterol dispersions or of dispersions saturated with N2O ave in low yields the products 38‐hydroxy‐cholest‐5‐en‐7‐one. the epimeric cholest‐5‐ene‐3β,7‐diols, 5,6α‐epoxy‐5α‐cholestan‐3β‐ol, 5.6β‐epoxy‐5β‐cholestan‐3,β‐ol, and 5α‐cholestane‐38,5,6β‐triol. Sterol hydroperoxides were not detected except in the radiolysis of dispersions saturated with oxygen. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：147 / 150

页数：4

共 19 条

[1]

AKHREM AA, 1974, DOKL AKAD NAUK SSSR+, V219, P891

[2]

BECKWITH ALJ, 1958, P CHEM SOC LONDON, P194

[3]

Bielsky BH., 1977, FREE RADICALS BIOL, V3, P1

[4] THE ACTION OF HYDROXYL RADICALS ON CHOLESTEROL AND SOME OF ITS ESTERS [J].

CLEMO, GR ;

KELLER, M ;

WEISS, J .

JOURNAL OF THE CHEMICAL SOCIETY, 1950, (DEC) :3470-3472

[5] CHEMICAL ACTIONS OF IONISING RADIATIONS IN SOLUTION .12. THE ACTION OF X-RAYS ON SOME STEROIDS IN ORGANIC SOLVENTS [J].

COLEBY, B ;

KELLER, M ;

WEISS, J .

JOURNAL OF THE CHEMICAL SOCIETY, 1954, (JAN) :66-71

[6] CHEMICAL ACTIONS OF IONISING RADIATIONS IN SOLUTION .6. RADIATION CHEMISTRY OF STEROLS - THE ACTION OF X-RAYS ON CHOLESTEROL AND 3-BETA-HYDROXYPREGN-5-EN-20-ONE [J].

KELLER, M ;

WEISS, J .

JOURNAL OF THE CHEMICAL SOCIETY, 1950, (OCT) :2709-2714

[7]

KIMURA M, 1973, CHEM PHARM BULL, V21, P2521

[8]

KIMURA M, 1972, CHEM PHARM BULL, V20, P2185

[9] STEROL METABOLISM .23. CHOLESTEROL OXIDATION BY RADIATION-INDUCED PROCESSES [J].

SMITH, LL ;

TENG, JI ;

KULIG, MJ ;

HILL, FL .

JOURNAL OF ORGANIC CHEMISTRY, 1973, 38 (09) :1763-1765

[10] DETECTION OF STEROL HYDROPEROXIDES ON THIN-LAYER CHROMATOPLATES BY MEANS OF WURSTER DYES [J].

SMITH, LL ;

HILL, FL .

JOURNAL OF CHROMATOGRAPHY, 1972, 66 (01) :101-&

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