STUDIES ON 1,2,3-TRIAZOLE DERIVATIVES AS INVITRO INHIBITORS OF PROSTAGLANDIN SYNTHESIS

被引：0

作者：

BIAGI, G ^{[1
]}

DELLOMODARME, G ^{[1
]}

FERRETTI, M ^{[1
]}

GIORGI, I ^{[1
]}

LIVI, O ^{[1
]}

SCARTONI, V ^{[1
]}

机构：

[1] UNIV PISA,IST CHIM FARMACEUT & TOSSICOL,VIA BONANNO 6,I-56100 PISA,ITALY

来源：

FARMACO | 1990年 / 45卷 / 11期

关键词：

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This paper reports some new structural modifications (branching and lengthening of alkanoic substituent, increase of heterocycle-carboxylate distance) on 1,2,3-triazole derivative 1, a potent in vitro inhibitor of prostaglandin synthesis, and their influence on enzyme activity. Regarding the structural relationship between 1 and Dazoxiben, a selective thromboxane-synthetase inhibitor, the preparation and activity of some Dazoxiben analogs bearing different heterocycles, are also described.

引用

页码：1181 / 1192

页数：12

共 11 条

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[2] BIAGI G, 1985, FARMACO-ED SCI, V40, P73
[3] BIAGI G, 1985, EUR J MED CHEM, V20, P267
[4] BIAGI G, 1988, FARMACO, V43, P597
[5] THE ACID-CATALYZED REACTION OF ALKYL AZIDES UPON CARBONYL COMPOUNDS
BOYER, JH
HAMER, J
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1955, 77 (04) : 951 - 954
[6] SELECTIVE THROMBOXANE SYNTHETASE INHIBITORS .1. 1-[(ARYLOXY)ALKYL]-1H-IMIDAZOLES
CROSS, PE
DICKINSON, RP
PARRY, MJ
RANDALL, MJ
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1985, 28 (10) : 1427 - 1432
[7] CROSS PE, Patent No. 2950019
[8] Durden J. A., 1964, J CHEM ENG DATA, V9, P228
[9] INION H, 1977, EUR J MED CHEM, V12, P483
[10] LIVI O, 1983, EUR J MED CHEM, V18, P471

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