BROAD-SPECTRUM ANTI-VIRAL AGENT RIBAVIRIN INHIBITS CAPPING OF MESSENGER-RNA

被引：189

作者：

GOSWAMI, BB ^{[1
]}

BOREK, E ^{[1
]}

SHARMA, OK ^{[1
]}

FUJITAKI, J ^{[1
]}

SMITH, RA ^{[1
]}

机构：

[1] UNIV CALIF LOS ANGELES,DEPT CHEM,LOS ANGELES,CA 90024

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 89卷 / 03期

关键词：

D O I：

10.1016/0006-291X(79)91853-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ribavirin (1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide) is a broad spectrum antiviral substance active against a wide range of both DNA and RNA viruses. It is, however, virtually inactive against polio virus. Its pharmacological mechanism of action was obscure. A possible common target for a chemotherapeutic agent in both DNA and RNA viruses is the capping" reaction of mRNAs which inter alia involves the formation of a guanine pyrophosphate structure at the 5′ terminus by mRNA guanylyl transferase. We have observed that Ribavirin triphosphate is a potent competitive inhibitor of the capping guanylation of viral mRNA. This finding could account for the antiviral potency of the drug against both DNA and RNA viruses and its ineffectiveness against a virus in which the mRNAs derived from them are not capped. © 1979."

引用

页码：830 / 836

页数：7

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