IDENTITY OF CHEMICAL AND HORMONAL PROPERTIES OF THYROTROPIN RELEASING HORMONE AND PYROGLUTAMYL-HISTIDYL-PROLINE AMIDE

被引：523
作者：
BOLER, J
ENZMANN, F
FOLKERS, K
BOWERS, CY
SCHALLY, AV
机构：
[1] The University of Texas at Austin, TX
[2] Tulane University School of Medicine, Veterans Administration Hospital New Orleans, LA
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1969年 / 37卷 / 04期
关键词：
D O I：
10.1016/0006-291X(69)90868-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The structure of L-pyroglutamyl-l-histidyl-l-proline amide (I) is in agreement with all Qf the known chemical and hormonal properties of the thyrotropin releasing hormone (TIM) from porcine hypothalami. This structural interpretation is probably applicable to the THE of other mammalian species, and is chemically based on the chromatographic identity in seventeen diversified systems and is biologically based on a quantitative comparison of the hormonal activities of the natural and synthetic products. This formulation of structure represents the elucidation of the first of the hypothalamic hormones that have been sought for so long. © 1969.
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页码：705 / &
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共 9 条
[1]   EFFECT OF THYROTROPIN RELEASING FACTOR (TRF) OF OVINE BOVINE PORCINE AND HUMAN ORIGIN ON THYROTROPIN RELEASE IN VITRO AND IN VIVO [J].
BOWERS, CR ;
REDDING, TW ;
SCHALLY, AV .
ENDOCRINOLOGY, 1965, 77 (04) :609-&
[2]   INTERACTIONS OF L-THYROXINE OR L-TRIIODOTHYRONINE AND THYROTROPIN-RELEASING FACTOR ON RELEASE AND SYNTHESIS OF THYROTROPIN FROM ANTERIOR PITUITARY GLAND OF MICE [J].
BOWERS, CY ;
SCHALLY, AV ;
REYNOLDS, GA ;
HAWLEY, WD .
ENDOCRINOLOGY, 1967, 81 (04) :741-+
[3]  
BOWERS CY, IN PRESS
[4]  
BURGUS R, 1969, CR ACAD SCI D NAT, V269, P226
[5]  
BURGUS R, 1969, CR ACAD SCI D NAT, V268, P2116
[6]  
FOLKERS K, IN PRESS
[7]  
Schally A V, 1968, Recent Prog Horm Res, V24, P497
[8]  
SCHALLY AV, 1969, J BIOL CHEM, V244, P4077
[9]   ISOLATION OF THYROTROPIN RELEASING FACTOR (TRF) FROM PORCINE HYPOTHALAMUS [J].
SCHALLY, AV ;
BOWERS, CY ;
REDDING, TW ;
BARRETT, JF .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1966, 25 (02) :165-&
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