Scientific Opinion on the identification of pesticides to be included in cumulative assessment groups on the basis of their toxicological profile

被引：119

作者：

Aagaard, Alf ^{[1
]}

Brock, Theo ^{[1
]}

Capri, Ettore ^{[1
]}

Duquesne, Sabine ^{[1
]}

Filipic, Metka ^{[1
]}

Hernandez-Jerez, Antonio ^{[1
]}

Hirsch-Ernst, Karen Ildico ^{[1
]}

Bennekou, Susanne Hougaard ^{[1
]}

Klein, Michael ^{[1
]}

Kuhl, Thomas ^{[1
]}

Laskowski, Ryszard ^{[1
]}

Liess, Matthias ^{[1
]}

Mantovani, Alberto ^{[1
]}

Ockleford, Colin ^{[1
]}

Ossendorp, Bernadette ^{[1
]}

Pickford, Daniel ^{[1
]}

Smith, Robert ^{[1
]}

Sousa, Paulo ^{[1
]}

Sundh, Ingvar ^{[1
]}

Tiktak, Aaldrik ^{[1
]}

Van Der Linden, Ton ^{[1
]}

机构：

[1] EFSA, Parma, Italy

来源：

EFSA JOURNAL | 2013年 / 11卷 / 07期

关键词：

Cumulative risk assessment; toxicological profile; methodology; cumulative assessment grouping; thyroid; nervous system;

D O I：

10.2903/j.efsa.2013.3293

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The European Food Safety Authority asked the Panel on Plant Protection Products and their Residues to develop an Opinion on the identification of pesticides to be included in cumulative assessment groups (CAGs) on the basis of their toxicological profile. In 2008, the PPR Panel adopted an Opinion on the suitability of existing methodologies for cumulative risk assessment of pesticides and a tiered approach was proposed, which was applied to a selected group of triazole pesticides in 2009. The present Opinion suggests a methodology for grouping of pesticides based on phenomenological effects and provides CAGs for the thyroid and nervous system. This approach can be applied even when the underlying biochemical events mediating the effects are not understood, and is based on a standardised and thorough review of Draft Assessment Reports (DARs) supporting the approval of all pesticides in Europe, and on recommendations from the European Commission. Pesticidal active substances exhibiting neurotoxic properties were allocated to CAGs for acute effects on motor, sensory and autonomic divisions of the nervous system and neurochemical endpoints. Chronic effects across the same divisions/endpoints and neuropathological effects were collated. Active substances having adverse effects on the thyroid system were allocated to CAGs for effects either on C-cells/the calcitonin system or on follicular cells/the T3/T4 system. The PPR Panel notes that the resulting groups encompass many pesticides and also that individual pesticides could appear in several groups and therefore the data entries for performing cumulative risk assessment (CRA) are of considerable magnitude. Although some CAGs contain a large number of pesticides, little indication of cumulative risk may be inferred from the size of CAGs per se. The PPR Panel recommends that the methodology is implemented for all major organ/systems but the approach used should be considered specific for pesticides. (C) European Food Safety Authority, 2014.

引用

页数：131

共 75 条

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