CYTOKINE GENE-EXPRESSION IN THE MIXED LYMPHOCYTE CULTURE IN ALLOGENEIC BONE-MARROW TRANSPLANTS AS A PREDICTIVE METHOD FOR TRANSPLANTATION-RELATED COMPLICATIONS

被引：21

作者：

TANAKA, J ^{[1
]}

IMAMURA, M ^{[1
]}

KASAI, M ^{[1
]}

KOBAYASHI, S ^{[1
]}

HASHINO, S ^{[1
]}

KOBAYASHI, H ^{[1
]}

SAKURADA, K ^{[1
]}

MIYAZAKI, T ^{[1
]}

机构：

[1] SAPPORO HOKUYU HOSP,DEPT INTERNAL MED,SHIROISHI KU,SAPPORO,HOKKAIDO,JAPAN

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1994年 / 87卷 / 02期

关键词：

BONE MARROW TRANSPLANTATION; CYTOKINE; GRAFT-VERSUS-HOST DISEASE; GRAFT FAILURE; MIXED LYMPHOCYTE CULTURE;

D O I：

10.1111/j.1365-2141.1994.tb04935.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We have investigated cytokine gene expression in the two-way mixed lymphocyte cultures (MLC) enhanced by concanavalin A to assess whether this is a useful predictive method for severe graft-versus-host disease (GVHD) and graft failure in nine allogeneic bone marrow transplantation (allo-BMT) patients. Our present study revealed that increased IL-2, IL-5 and IFN-gamma mRNA expression and IL-2 and IFN-gamma production in the MLC in two cases with severe lethal transplantation-related complications (graft failure and grade III acute GVHD). These findings suggest that increased cytokine mRNA expression and cytokine products in this assay may be predictive of the development of transplantation-related complications.

引用

页码：415 / 418

页数：4

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