EVALUATION OF A BROTH MICRODILUTION ANTIFUNGAL SUSCEPTIBILITY TEST WITH A PH INDICATOR - COMPARISON WITH THE BROTH MACRODILUTION PROCEDURES

被引：9
作者：
FOURNIER, C
GASPAR, A
BOILLOT, F
VILLARD, J
机构：
[1] Laboratoire de Mycologie, Fondamentale et Appliquée, Biotechnologies Industrielles Faculté de Pharmacie, 69373 Lyon Cedex 08
来源：
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 1995年 / 35卷 / 03期
关键词：
D O I：
10.1093/jac/35.3.373
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
A broth microdilution antifungal susceptibility test with a pH indicator (bromocresol purple) in a synthetic medium was evaluated. This method measures cellular activity instead of simply a change in biomass. The variations of pH caused by fungal activity were measured by changes in optical densities at 450 nm. The MICs(50) obtained were compared with the MICs found by the classical broth macrodilution procedure. In most cases broth micro- and macrodilution MICs were in agreement for amphotericin B, fluconazole, flucytosine and nystatin.
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页码：373 / 380
页数：8
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