FROM CHLOROBENZENE TO A CARBOHYDRATE IN 2 STEPS - A NEW CHEMOENZYMATIC SYNTHESIS OF 2,3-O-ISOPROPYLIDENE-D-ERYTHRURONOLACTONE

被引：10

作者：

MANDEL, M

HUDLICKY, T

KWART, LD

WHITED, GM

机构：

[1] VIRGINIA POLYTECH INST & STATE UNIV,BLACKSBURG,VA 24061

[2] GENENCOR INT INC,S SAN FRANCISCO,CA 94080

来源：

COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS | 1993年 / 58卷 / 10期

关键词：

D O I：

10.1135/cccc19932517

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Controlled oxidation of chloroepoxide V with two equivalents of sodium periodate furnished 2,3-O-isopropylidene-D-erythruronolactone (I) in 63% yield. This procedure was augmented by combining the protection of diol III, the oxidation of acetonide IV to V, and the subsequent oxidative cleavage to I into one operation which yielded, on medium scale, the title lactone in 51% yield. Detailed procedure of preparation and physical constants are provided for lactone I.

引用

页码：2517 / 2522

页数：6

共 16 条

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