A MICROSATELLITE-BASED INDEX MAP OF HUMAN CHROMOSOME-11

被引：56

作者：

LITT, M

KRAMER, P

HAUGE, XY

WEBER, JL

WANG, Z

WILKIE, PJ

HOLT, MS

MISHRA, S

DONISKELLER, H

WARNICH, L

RETIEF, AE

JONES, C

WEISSENBACH, J

机构：

[1] MARSHFIELD MED RES FDN,MARSHFIELD,WI 54449

[2] WASHINGTON UNIV,ST LOUIS,MO 63110

[3] UNIV STELLENBOSCH,STELLENBOSCH 7600,SOUTH AFRICA

[4] ELEANOR ROOSEVELT INST CANC RES,DENVER,CO 80206

[5] GENETHON,F-91002 EVRY,FRANCE

来源：

HUMAN MOLECULAR GENETICS | 1993年 / 2卷 / 07期

关键词：

D O I：

10.1093/hmg/2.7.909

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have constructed a continuous index map of 25 microsatellite markers on human chromosome 11. The markers have been typed in 40 CEPH families, have heterozygosities of 69% or higher and can be typed by PCR. The odds against inversion of adjacent marker loci order are at least 10(5):1. The sex average map covers a total of 162 cM with no gap exceeding 15 cM. Total lengths for female and male maps are 205 and 123 cM, respectively. By use of a hybrid cell panel or by in situ hybridization, 16 of the markers have also been mapped cytogenetically, providing a good correlation of the index map with the cytogenetic map. The map will facilitate high resolution mapping of additional polymorphic loci and of disease genes on chromosome 11.

引用

页码：909 / 913

页数：5

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