EFFECT OF PROPRANOLOL PHENTOLAMINE AND PIMOZIDE ON DRUG-INDUCED ANOREXIA IN THE MOUSE

被引：17

作者：

DOBRZANSKI, S ^{[1
]}

DOGGETT, NS ^{[1
]}

机构：

[1] UWIST,WELSH SCH PHARM,DEPT PHARMACOL,CARDIFF CF1 3NU,S GLAMORGAN,WALES

来源：

PSYCHOPHARMACOLOGY | 1979年 / 66卷 / 03期

关键词：

(+)Amphetamine; Diethylproprion; Dopaminergic receptors; Mazindol; Noradrenergic receptors; Phentermine;

D O I：

10.1007/BF00428323

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Pimozide was a potent antagonist of (-)amphetamine, diethylpropion, mazindol and phentermine anorexia in the mouse. Phentolamine and propranolol produced no such antagonism, but either potentiated or had no effect on the drug-induced anorexia. Although the mechanism of action of the four anorectic agents appears to involve dopamine receptor agonist activity, an antagonist or partial agonist effect at noradrenergic receptors may also be involved. © 1979 Springer-Verlag.

引用

页码：297 / 300

页数：4

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