POLYSTYRENE-SUPPORTED SYNTHESIS BY THE PHOSPHITE TRIESTER APPROACH - AN ALTERNATIVE FOR THE LARGE-SCALE SYNTHESIS OF SMALL OLIGODEOXYRIBONUCLEOTIDES

被引：19

作者：

BARDELLA, F ^{[1
]}

GIRALT, E ^{[1
]}

PEDROSO, E ^{[1
]}

机构：

[1] UNIV BARCELONA, FAC QUIM, DEPT QUIM ORGAN, MARTI & FRANQUES 1, E-08028 BARCELONA, SPAIN

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 43期

关键词：

D O I：

10.1016/S0040-4039(00)97032-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The large scale synthesis of two octadeoxyribonuclcotides has been successfully accomplished on polystyrene by the phosphite triester approach. Employing moderate excesses but high concentrations of phosphoramidites, the coupling yields are similar to those obtained in standard small scale syntheses. © 1990.

引用

页码：6231 / 6234

页数：4

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