MIGRAINE PAIN ASSOCIATED WITH MIDDLE CEREBRAL-ARTERY DILATATION - REVERSAL BY SUMATRIPTAN

被引:338
作者
FRIBERG, L [1 ]
OLESEN, J [1 ]
IVERSEN, HK [1 ]
SPERLING, B [1 ]
机构
[1] GENTOFTE HOSP,DEPT NEUROL,DK-2900 COPENHAGEN,DENMARK
关键词
D O I
10.1016/0140-6736(91)90005-A
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The combination of measurements of regional cerebral blood flow (rCBF) and blood velocity in the middle cerebral arteries (MCA) by transcranial doppler sonography was used to investigate cerebrovascular involvement in migraine. Ten migraine patients with unilateral headache were studied during an attack and when they had been free of attacks for 5 days (non-attack). On both occasions they were given an intravenous infusion of sumatriptan (2 mg), a 5-HT1-like receptor agonist, which relieved the symptoms within 30 min without affecting rCBF. The MCA velocity was normal on both sides on the non-attack day and on the unaffected side during the attack. However, during the attack the MCA velocity on the headache side was significantly lower than that on the nonheadache side (45 vs 61 cm/s:mean difference 16.3 [95% confidence interval 10.3-22.3]; p = 0.02). The MCA velocity on the headache side returned to normal after treatment with sumatriptan and recovery. Since rCBF in the MCA supply territory was unaffected, the lower velocity can be explained only by dilatation of the MCA. The mean MCA diameter increase was estimated to be 20%. Thus, headache was associated with intracranial large arterial dilatation on the headache side. Sumatriptan predominantly had effects on the distended artery, which suggests that the 5-HT receptor system has a role in the pathogenesis of migraine.
引用
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页码:13 / 17
页数:5
相关论文
共 29 条
[1]  
AASLID R, TRANSCRANIAL DOPPLER, P19
[2]   DELAYED HYPEREMIA FOLLOWING HYPOPERFUSION IN CLASSIC MIGRAINE - SINGLE PHOTON-EMISSION COMPUTED TOMOGRAPHIC DEMONSTRATION [J].
ANDERSEN, AR ;
FRIBERG, L ;
OLSEN, TS ;
OLESEN, J .
ARCHIVES OF NEUROLOGY, 1988, 45 (02) :154-159
[3]  
ATKINS HL, 1980, J NUCL MED, V21, P459
[4]   A METHOD FOR CALCULATING REGIONAL CEREBRAL BLOOD-FLOW FROM EMISSION COMPUTED-TOMOGRAPHY OF INERT-GAS CONCENTRATIONS [J].
CELSIS, P ;
GOLDMAN, T ;
HENRIKSEN, L ;
LASSEN, NA .
JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 1981, 5 (05) :641-645
[5]  
DECLERCK F, 1985, SEROTONIN CARDIOVASC, P155
[6]  
DOENICKE A, 1988, LANCET, V1, P1309
[7]  
EDVINSSON L, 1989, CEPHALALGIA S10, V9, P39
[8]   THE SELECTIVE CAROTID ARTERIAL VASOCONSTRICTOR ACTION OF GR43175 IN ANESTHETIZED DOGS [J].
FENIUK, W ;
HUMPHREY, PPA ;
PERREN, MJ .
BRITISH JOURNAL OF PHARMACOLOGY, 1989, 96 (01) :83-90
[9]   FOCAL ISCHEMIA CAUSED BY INSTABILITY OF CEREBROVASCULAR TONE DURING ATTACKS OF HEMIPLEGIC MIGRAINE - A REGIONAL CEREBRAL BLOOD-FLOW STUDY [J].
FRIBERG, L ;
OLSEN, TS ;
ROLAND, PE ;
LASSEN, NA .
BRAIN, 1987, 110 :917-934
[10]  
Friberg L, 1989, CEPHALALGIA S10, V9, P29