AUTOCRINE GROWTH BY 2 CYTOKINES, INTERLEUKIN-6 AND TUMOR NECROSIS FACTOR-ALPHA, IN THE MYELOMA CELL-LINE KHM-1A

被引：32
作者：
HATA, H [1 ]
MATSUZAKI, H [1 ]
TAKATSUKI, K [1 ]
机构：
[1] KUMAMOTO UNIV,SCH MED,DEPT INTERNAL MED 2,HONJO 1-1-1,KUMAMOTO 860,JAPAN
来源：
ACTA HAEMATOLOGICA | 1990年 / 83卷 / 03期
关键词：
Autocrine; Interleukin-6; Myeloma; Tumor necrosis factor;
D O I：
10.1159/000205189
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The effects of tumor necrosis factor α (TNF-α) and interleukin-6 (IL-6) on the cell growth of the myeloma cell line KHM-1A were studied. TNF-α strongly induced KHM-1A proliferation, while IL-6 weakly enhanced growth only at low cell densities. When TNF-α was combined with IL-6, TNF-α-induced growth enhancement was reduced. According to Northern blotting analysis, the m-RNA of both TNF-α and IL-6 were detected in KHM-1A. Moreover, monoclonal antibody capable of neutralizing the cytotoxic activity of TNF-α inhibited the proliferation of this cell line. These findings suggest that this cell line operates under an autocrine growth mechanism with respect to these two cytokines, IL-6 and TNF-α
引用
收藏
页码：133 / 136
页数：4
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